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KMID : 1030220140150040202
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Journal of Korean Diabetes
2014 Volume.15 No. 4 p.202 ~ p.205
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HbA1c Variability and Micro- and Macrovascular Complications of Diabetes
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Yang Hae-Kyung
Lee Seung-Hwan
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Abstract
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Glycemic variability comprises ‘glucose variability’ and ‘hemoglobin A1c (HbA1c) variability.’ Glucose variability relates to the within-day fluctuation of glucose level and may eventually reflect an increase in HbA1c level. Long-term glycemic variability, which is assessed by HbA1c fluctuation, reflects changes in glycemia over longer periods of time. Previous reports from several cohort studies have demonstrated that HbA1c variability is associated with the development or progression of microvascular complication in type 1 and 2 diabetes mellitus. However, data on the impact of HbA1c variability on macrovascular complications are controversial, and little is known about its impact on mortality. Further studies with a larger population including various ethnic groups are required to verify the impact of HbA1c variability on micro- and macrovascular complications of diabetes. Also, stabilized control of long-term glucose level should be emphasized based on these study results.
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KEYWORD
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Complication, Diabetes mellitus, HbA1c
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